The third seminar in the CLOSER Longitudinal Methodology Series features a talk from Dr Graciela Muniz Terrera, Programme Track Leader at the MRC Unit for Lifelong Health and Ageing at UCL.
About the CLOSER Longitudinal Methodology Series
The aim of the series is to highlight methodological innovations and expertise and in turn facilitate and encourage future collaborations and new research.
Dr Graciela Muniz-Terrera
Are time in study and age exchangeable as metric of time when modelling change in age heterogeneous longitudinal studies?
In cognitive ageing research, investigators often model cognitive decline fitting longitudinal models that describe change as a function of some metric of time. For instance, when modelling preclinical dementia trajectories, dementia diagnosis is often used to define the time metric and change is modelled as a function of time to diagnosis. When interested in understanding changes before death, the metric of time often considered is time to death. Researchers using these metrics of time assume that changes in the process being modelled is driven by the event used to define the time metric (dementia or death in the previous examples).
Yet, most often, the focus of ageing research is developmental change. In this context, cognitive changes are often modelled as a function of time in study or age and both metrics of time are used almost interchangeably in the literature.
In this presentation I will discuss some issues that arise when modelling change as a function of time in study and as a function of age.
I will illustrate the different points modelling change in perceptual speed scores from participants of a longitudinal study of cognitive ageing.
Authors: Graciela Muniz-Terrera (MRC Lifelong Health and Ageing Unit at UCL) & Andrea Piccinin (Dept. of Psychology, University of Victoria, Canada)