The MRC National Survey of Health of Development (NSHD) assessed their cohort members (CMs) during the study’s age 68-70 sweep using the Addenbrooke’s Cognitive Examination-III (ACE-III).
Details on this measure and the data collected from the CMs are outlined in the table below.
|Domain:||Verbal and non-verbal ability|
|CHC:||G (general ability)|
|Administration method:||Research nurse. Mostly conducted using ACEmobile app, installed on iPad, with prompts to guide interviewer through the process. Pen and paper used where necessary (e.g. drawing tests).|
|Procedure:||The ACE-III was designed to detect mild dementia and distinguish between Alzheimer's disease (AD) and Frontotemporal dementia (FTD) (Mathuranath et al., 2000). Although it may be considered a measure of general cognitive ability, it was developed as a screen for impairment for use in clinical settings. It contains tasks/questions that measure 5 different cognitive domains: attention and orientation (scored 0 - 18); verbal fluency (0 - 14); memory (0 - 26); language (0 - 26); and visuospatial function (0 - 16). The tasks/questions used to assess the 5 specific domains are outlined separately in the next sections. Responses from the 5 domains can be summed to create an overall cognitive functioning score (0 - 100). ACE-III was administered by the interviewers via iPad using ACEmobile (http://www.acemobile.org). Where this was not possible, a paper version was used. All offline scoring was undertaken by trained personnel.|
|Link to questionnaire:||https://skylark.ucl.ac.uk/NSHD/lib/exe/fetch.php?media=mrepo:ace-iii.pdf (opens in new tab)|
|Scoring:||One mark per correct item (0 - 100)|
|Item-level variable(s):||ACESCRAT15x - ACEVISIOTOT15x|
|Total score/derived variable(s):||ACETOTFIN15x, MINIACE15x|
|N = 1,762|
|Range = 53 - 100|
|Mean = 91.52|
|SD = 6.01|
|(click image to enlarge)
|Age of participants (months):||Mean = 834.14, SD = 2.93, Range = 828 - 848|
|Other sweep and/or cohort:||None|
|Source:||Mathuranath, P. S., Nestor, P. J., Berrios, G. E., Rakowicz, W., & Hodges, J. R. (2000). A brief cognitive test battery to differentiate Alzheimer's disease and frontotemporal dementia. Neurology, 55(11), 1613-1620.|
|Technical resources:||Noone, P. (2015). Addenbrooke's cognitive examination-III. Occupational Medicine, 65(5), 418-420.|
|Reference examples:||Matías-Guiu, J. A., Valles-Salgado, M., Rognoni, T., Hamre-Gil, F., Moreno-Ramos, T., & Matías-Guiu, J. (2017). Comparative diagnostic accuracy of the ACE-III, MIS, MMSE, MoCA, and RUDAS for screening of Alzheimer Disease. Dementia and Geriatric Cognitive Disorders, 43(5-6), 237-246.|
|James, S. N., Davis, D., O'Hare, C., Sharma, N., John, A., Gaysina, D., ... & Richards, M. (2018). Lifetime affective problems and later-life cognitive state: Over 50 years of follow-up in a British birth cohort study. Journal of Affective Disorders, 241, 348-355.|
- Overview of all cognitive measures in NSHD
- Overview of adulthood cognitive measures across all studies
This page is part of CLOSER’s ‘A guide to the cognitive measures in five British birth cohort studies’.